Table 1.
Genes in close association with both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) etiologies.
| Gene | Location | Pathway | MI |
|---|---|---|---|
| C9orf72 | 9p21.2 | Nucleocytoplasmic transport/splicing | AD |
| TBK1 | 12q14.1 | Autophagy/inflammation | AD |
| TARDBP | 1p36.2 | Nucleocytoplasmic transport/splicing | AD |
| SQSTM1 | 5q35.3 | Autophagy | AD/Risk |
| VCP | 9p13.3 | Autophagy/mitochondrial function | AD |
| FUS | 16p11.2 | Nucleocytoplasmic transport/splicing | AD/AR |
| UBQLN2 | Xp11 | Autophagy/proteasome | XL |
| CHCHD10 | 22q11.2 | Mitochondrial dysfunction/synaptic integrity | AD |
MI, mode of inheritance; AAO, age at onset; DM, disease modifier; AD, autosomal dominant; AR, autosomal recessive; XL, X-linked.