Fig. 5.

ROS scavenger and AQP4 enhancer reduce perihematomal edema via improvement of blood–brain barrier integrity. a Dosing schedule of the ROS scavengers (NAC, Trolox) and the AQP4 enhancer (BQ-788) and the MRI schedule. b T2-weighted MRI images acquired at 1, 3, and 7 days after intracerebral hemorrhage showing the areas of PHE and hematoma. c Evans blue leakage assay demonstrating the improving leakages by ROS scavenger (NAC and Trolox) and AQP4 enhancer (BQ-788) (magnification, × 20). d Survival curves of the mice after intracerebral hemorrhage. e, f, g Changes in the sizes of hematoma, edema, and EED in the PHE region at 1, 3, and 7 days after intracerebral hemorrhage in mice. Scale bar, 50 μm. Data are mean ± SD