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. 2021 Nov 11;18(4):2484–2503. doi: 10.1007/s13311-021-01151-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Systemic administration of the AAV-hE2F4DN vector prevents NT in h5xFAD mice. (a) NT quantification, normalized to NT levels in the cerebral cortex of 2-month-old WT mice, in cell nuclear extracts from the cerebral cortex of 2-month-old h5xFAD mice subjected to systemic administration of the AAV-EGFP control vector or the AAV-hE2F4DN vector at 1.5 months of age. Dashed line: NT in the cerebral cortex of 2-month-old WT mice. (t(9) = 4.66173, p = 0.0012; two-tailed Student’s t test). (b) Percentage of tetraploid neurons, normalized to NT levels in the cerebral cortex of 2-month-old WT mice, plotted against the expression levels of E2f4dn mRNA (normalized to Rps10 rRNA). A statistically significant correlation was observed (p < 0.005; Pearson’s R correlation test)