Table 4.

Treatment strategies in GJB1Cx32-associated neuropathies

Treatment	Mechanism	Model	Reference
GJB1/Cx32 gene delivery	Connexin 32 expression	Cx32 null mice	Sargiannidou (2015), Kagiava (2016), Kagiava (2019)
PLX5622	CSF-1 receptor kinase inhibitor	Cx32 null mice	Klein (2015)
KN 93	Ca2 + /calmodulin-dependent protein kinase II (CamKII)	Transgenic GJB1 mice	Mones (2014)
AAV1.NT-3 gene therapy	NT-3 secretion	Cx32 null mice	Ozes (2021)

GLB1 Gap junction beta-1, Cx32 connexin 32, CSF-1 colony-stimulating factor 1, AAV1 adeno-associated virus 1, NT-3 neurotrophin-3