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. 2022 Jan 29;44:101273. doi: 10.1016/j.eclinm.2022.101273

Table 3.

MPA Concentrations (ng/mL) by Injection Site, PK Population.

Geometric Mean Ratio (95% CI)
Abdomen Upper Thigh Back of Upper Arm Abdomen vs. Thigh Abdomen vs. Arm Thigh vs. Arm
C2mo
 GM (%CV) 0.46 (52.4) 0.32 (43.7) 0.42 (54.0) 1.42 (1.15, 1.74) 1.08 (0.85, 1.39) 0.77 (0.59, 0.99)
 P10 - P90* 0.29 - 0.68 0.18 - 0.55 0.23 - 0.77
 % < 0.2 ng/mL 0.0 12.5 6.5
Total 34 32 31
C3mo
 GM (%CV) 0.34 (39.5) 0.30 (48.9) 0.29 (53.3) 1.15 (0.93, 1.43) 1.16 (0.91, 1.49) 1.01 (0.77, 1.31)
 P10 - P90* 0.23 - 0.48 0.17 - 0.54 0.18 - 0.69
 % < 0.2 ng/mL 8.8 22.6 16.1
Total 34 31 31
C4mo
 GM (%CV) 0.27 (43.7) 0.24 (42.3) 0.22 (42.3) 1.10 (0.86, 1.40) 1.20 (0.93, 1.54) 1.09 (0.86, 1.38)
 P10 - P90* 0.13 - 0.41 0.14 - 0.43 0.14 - 0.42
 % < 0.2 ng/mL 18.2 29.0 32.3
Total 33 31 31
C8mo
 GM (%CV) 0.43 (34.8) 0.37 (35.9) 0.26 (41.2) 1.14 (0.92, 1.42) 1.65 (1.17, 2.32) 1.44 (1.01, 2.06)
 P10 - P90* 0.25 - 0.66 0.24 - 0.63 0.18 - 0.49
 % < 0.2 ng/mL 3.3 7.4 12.0
Total 30 27 25
C12mo
 GM (%CV) 0.48 (29.4) 0.41 (29.6) 0.32 (43.0) 1.17 (0.98, 1.39) 1.49 (1.15, 1.94) 1.28 (0.97, 1.67)
 P10 - P90* 0.30 - 0.72 0.25 - 0.58 0.20 - 0.57
 % < 0.2 ng/mL 0.0 0.0 13.6
Total 29 22 22

P10 and P90 are the 10th and 90th percentiles respectively.