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. 2022 Jan 18;12:763866. doi: 10.3389/fphar.2021.763866

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Copyright © 2022 Wang, Huang, Lu, Chen and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRPV1 activation rescued microglial neuroimmune suppression in 3xTg mice. (A, B) Histograms depicted quantitative analysis of average branch length (A) and number of end-point voxels (B) of Iba-1⁺ microglia. (C) Heatmap represented 320 differentially expressed microglial neuroimmune genes. (D) Z-score of genes from neuroimmune suppression cluster for all groups. (E) Histogram depicted top differentially expressed neuroimmune suppression cluster genes from the heatmap (criteria: p value of 3xTg and 3xTg + capsaicin low to high). n = 3 mice in each group. Data are presented as mean ± SEM, ^* p < 0.05, ^** p < 0.001, ^**** p < 0.0001. Statistical tests: one-way ANOVA with Tukey’s multiple comparison test.