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. 2022 Jan 18;8:797630. doi: 10.3389/fmed.2021.797630

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Copyright © 2022 Zong, Cheng, Li, Xue, Chen, Liu and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Boxplots show significantly altered metabolites in the tears of SLK patients. Compared with Control subjects, 19 decreased metabolites and 31 increased metabolites represented by relative expression in the boxplot (SLK vs. Ctrl: P < 0.05). Specifically, for better visualization of box plots in this analysis, the expressions of the metabolites was converted into log2(x + 1) values and a different Y-axis scales and range were applied in (A,B). (A) Metabolites with maximum converted values less than 1 [log2(x + 1) ≤ 1], (B) Metabolites with maximum converted values more than 1 [log2(x + 1) > 1]. Both figures present increased metabolites in the left [20 in (A), 11 in (B)] and decreased metabolites in the right [7 in (A), 12 in (B)], separated by two tick intervals.