Fig. 1.

- A - Recording of H₂O₂ concentration dynamics in striatal slices evoked by exogenous local application of a 1 mM H₂O₂ solution. Blue trace represents the amperometric current measured at the CFM-RP-Nafion® H₂O₂ sensor while the grey trace represents the current recorded at a null sensor. Repeated application of H₂O₂ through a micropipette place between the 2 sensors produced transient and reproducible increase in H₂O₂ in the brain tissue. B – Average of 44 individual normalized signals (blue) and first order exponential decay function (red). Inset is a schematic representation of the experimental design used, including the microelectrodes and ejection pipette between the two, where d is the distance between the micropipette tip and each of the sensors, v is the volume of the H₂O₂ solution ejected from the micropipette and r is the calculated radius of the bolus of H₂O₂ ejected. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)