Table 2.
Comparative analysis of half-life and apparent diffusion coefficient for H2O2 and other species acting as volume transmission molecules (•NO and dopamine) as well as the fast-excitatory neurotransmitter glutamate. Nitrite has been included to show the effect of charge on a small molecule.
| Analyte | Experimental Model | t1/2 (s) | D* (x 10−5 cm2 s−1) | Ref |
|---|---|---|---|---|
| H2O2 | In vivo in the rat striatum | 2.2 | 2.5 | Present Study |
| •NO | In vivo in the rat cortex | 0.6 | 3.3 | [36] |
| Dopamine | Midbrain slices from Guinea pig | 8.1 | 0.69 | [37] |
| Nitrite | In vivo in the rat cortex | n.d. | 0.63 | [36] |
| Glutamate | Mathematical Modelling | n.d. | 0.25 | [38] |