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. 2021 Dec 16;13(3):879–899. doi: 10.1016/j.jcmgh.2021.12.008

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Lipidomics of liver from WT and Tm6sf2 KO rats. Livers were collected from chow-fed 6-week-old male rats (n = 3/group) after a 16-hour fast. The fatty acid composition of TGs, CEs, PC, and PE were measured and analyzed by LC-MS as described in the Methods section. Fatty acid content was normalized to the amount of proteins, and presented as fold differences between genotypes. Bars indicate means ± SD. Differences between groups were analyzed using the Student unpaired 2-tailed t test. ∗P < .05, ∗∗P < .01. ∗∗∗P < .001. The experiment was repeated twice and the results were similar.