Skip to main content
. 2022 Jan 18;9:784983. doi: 10.3389/fcell.2021.784983

FIGURE 2.

FIGURE 2

Signaling functions of SDC-1 relevant to cell metastasis and invasion. (A) SDC-1 interacts with a vast number of extracellular matrix molecules such as MMP9, ICAM1, fibronectin, laminin, thrombospondin, and collagen; such interactions are facilitated via multivalent binding of these molecules to HS chains, thereby influencing cellular adhesive properties. (B) The HS chains of SDC-1 can bind extracellular Hsp90 to promote EGFR/HER2 dimerization and induce metastasis. (C). Shed SDC-1/HGF complex stimulates cell migration via the c-Met receptor. (D). Shed SDC-1 binds VEGF to promote endothelial cell invasion. (E). Nuclear translocation of SDC-1 modulates the EMT via interaction with Snail, resulting in enhanced tumor cell invasiveness.