TABLE 2.
The targeting of SDC-1 and SDC-1-related proteins by microRNA.
| Target (gene) | Potential microRNA | Mechanism of action | Cancer | References |
|---|---|---|---|---|
| SDC-1 | miR-494 | Inhibition of SDC-1 shedding; inhibition of MMP-9, VEGF, and HIF1a; suppression of angiogenesis | Medulloblastoma | Asuthkar et al. (2014) |
| miR-302a | Inhibition of the transition from G1 to S phases; inhibition of cell growth; increase in apoptosis | Ovarian cancer | Guo et al. (2015) | |
| miR-515-5p | Inhibition of cell proliferation, migration, invasion, and colony formation; increase in rate of cell apoptosis | Bladder cancer | Cao et al. (2021) | |
| Heparanase | miR-155-based artificial miRNA | Suppression of melanoma cell adhesion, migration and invasiveness | Melanoma | Liu et al. (2012) |
| Lentiviral miR-30-based RNA interference | Suppression of melanoma cell adhesion, migration and invasiveness | Melanoma | Liu et al. (2013) | |
| SDCBP | miR-135a-5p/miR-124-3p | Inhibition of tumor growth; decrease in tumor size; prolong survival time | Glioblastoma | Lin et al. (2018) |
| miR-361-5p | Inhibition of cell proliferation and tumor growth; increase in apoptosis | Gastric carcinoma | Qian et al. (2020) | |
| miR-135b-5p | Inhibition of the epithelial-mesenchymal transition; decrease in migration | Breast cancer | Pu et al. (2019) | |
| miR-1273a | Enhancement of cisplatin cytotoxicity; prevention of chemoresistance | Non-small cell lung cancer | Zhao et al. (2020) |