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Risk of bias of included trials.
| Trial | Randomisation process | Deviations from intended interventions | Missing outcome data | Measurement of the outcome | Selection of the reported result | Overall bias |
|---|---|---|---|---|---|---|
| COU-AA-301 | Low | Low | Low | Low | Low | Low |
| Sun et al. (2016) | Low | Low | Low | Low | Low | Low |
| AFFIRM | Low | Low | Low | Low | Low | Low |
| TROPIC | Low | Some concerns | Low | Some concerns | Low | Some concerns |
| ALSYMPCA | Low | Low | Low | Some concerns | Some concerns | Some concerns |
