TABLE 2.
The potential of circRNAs in the diagnosis and prognosis of pediatric malignant soild tumor.
| Study | Sample size | circRNAs | Expression | Source | Expression (p value) | Diagnostic value AUC | Sample size | Prognostic value OS (p value) | References |
|---|---|---|---|---|---|---|---|---|---|
| Hepatoblastoma | |||||||||
| Zhen et al | (Normal:Tumor) | circ-HMGCS1 | Up | Tissues | p < 0.001 | 0.8283 | Tumor (n = 33) | p = 0.0497 | Zhen et al. (2019) |
| (37:37) | |||||||||
| Neuroblastoma | |||||||||
| Yang et al | (Normal:Tumor) | circ-DGKB | Up | Blood | p < 0.05 | 0.7778 | Tumor (n = 33) | p = 0.0324 | Yang et al. (2020) |
| (10:30) | |||||||||
| Zhang et al | (Normal:Tumor) | circ-CUX1 | Up | Tissues | p < 0.05 | - | Tumor (n = 50) | p = 0.0120 | Zhang et al. (2020) |
| (50:50) | |||||||||
| Lymphoma | |||||||||
| Mei et al | (Normal:Tumor) | circ-CDYL | Up | Tissues | p < 0.001 | 0.856 | Tumor (n = 18) | p = 0.595 | Mei et al. (2019) |
| (17:18) | |||||||||
| Adrenocortical Carcinoma | |||||||||
| Li et al | (Normal:Tumor) | circ-CCAC1 | Up | Tissues | p < 0.01 | - | Tumor (n = 48) | p = 0.006 | Li et al. (2020a) |
| (48:48) | |||||||||