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. 2022 Jan 18;12:773150. doi: 10.3389/fphar.2021.773150

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Copyright © 2022 Wu, Li, Shen, Li, Yu, Li, Deng, Liu, Zhang, Xu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Micheliolide (MCL) mediates autophagy of the NLRP3 inflammasome (A–B) HIECs were stained for LC3/LAMP1 (green) and NLRP3 (red) and analyzed by confocal microscopy. Co-localization of NLRP3 (arrows) and LC3/LAMP1 (arrowheads) is apparent. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, two-tailed Student’s t-test. Con, untreated HIECs; IR, HIECs exposed to radiation (10 Gy); IR + MCL, HIECs pretreated with MCL (10 μM) prior to radiation (10 Gy) exposure; HIEC, human intestinal epithelial cell; LC3/LAMP1, light chain three/lysosome-associated membrane protein.