Table 3.

Univariate and multivariate analysis of risk factors of tumor recurrence in 122 patients.

	Univariate		Multivariate
	HR (95%CI)	P	HR (95%CI)	p
Age ≥55	0.88 (0.57–1.36)	0.576
male	0.57 (0.28–1.14)	0.111
Size ≥ 5cm	1.9 (1.12 –3.24)	0.018	2.13 (1.23–3.69)	0.007
Multiple tumors	1.44 (0.92–2.25)	0.114
Vascular invasion
Macro-VI	2.41 (1.52–3.84)	<0.001	2.08 (1.29–3.37)	0.003
Micro-VI	1.5 (0.97–2.34)	0.071	1.61 (1.02–2.55)	0.042
Poor differentiation	1.15 (0.75–1.76)	0.516
Child B	1.1 (0.48–2.50)	0.823
AFP ≥200	1.61 (1.04–2.49)	0.032	1.42 (0.91–2.20)	0.122
PD-L1 ≥3.0	1.66 (1.07–2.57)	0.023	1.88 (1.18–2.99)	0.008
PD-1 >1.0	1.31 (0.81–2.14)	0.269
Liver cirrhosis	1.28 (0.82–2.00)	0.281

HRs, hazards ratios; CI, confidence intervals; AFP, alpha fetoprotein; PD-L1, programmed death-ligand 1; PD-1, programmed cell death protein 1.