Table 5.
Candidate miRNA–mRNA pairs involved in Marsupenaeus japonicus intestinal immune response against DIV1.
| DEM name | Target DEG Name | Homolog Function | Species | MiRNAlog2FC | Targetlog2FC |
|---|---|---|---|---|---|
| Toll and IMD signaling pathways | |||||
| novel_mir40 | CL5325.Contig5_All | Ankyrin-1-like | M. japonicus | −1.20 | 1.49 |
| novel_mir58 | CL2943.Contig1_All | Transcription factor ATF-2 | Litopenaeus vannamei | −1.50 | 1.34 |
| novel_mir60 | CL5043.Contig4_All | Ankyrin-1-like | L. vannamei | −0.43 | 1.61 |
| novel_mir60 | CL5043.Contig5_All | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like | Amphimedon queenslandica | −0.43 | 1.30 |
| novel_mir73 | CL3555.Contig2_All | Immune deficiency homolog | M. japonicus | 7.53 | −1.81 |
| novel_mir82 | CL348.Contig1_All | Caspase 4 | L. vannamei | −4.44 | 1.43 |
| novel_mir86 | CL4844.Contig2_All | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like isoform X1 | L. vannamei | 2.50 | −1.10 |
| IL-17 signaling pathway | |||||
| miR-6493-5p | Unigene12925_All | Mucin-5AC-like isoform X2 | Habropoda laboriosa | 2.21 | −2.86 |
| miR-750_3 | CL1703.Contig2_All | Uncharacterized protein LOC113809504 | L. vannamei | −3.29 | 1.24 |
| novel_mir56 | CL2784.Contig3_All | Uncharacterized protein LOC113823076 | L. vannamei | 4.21 | −5.43 |
| novel_mir56 | CL2784.Contig5_All | Uncharacterized protein LOC113823075 isoform X3 | L. vannamei | 4.21 | −2.93 |
| novel_mir56 | CL917.Contig2_All | UNC93-like protein MFSD11 | L. vannamei | 4.21 | −1.89 |
| novel_mir56 | Unigene3462_All | Uncharacterized protein LOC113822805 | L. vannamei | 4.21 | −1.18 |
| novel_mir58 | Unigene20728_All | Hypothetical protein C7M84_008404 | L. vannamei | −1.50 | 4.81 |
| novel_mir60 | CL1388.Contig1_All | Hypothetical protein C7M84_016913 | L. vannamei | −0.43 | 3.13 |
| novel_mir63 | CL1768.Contig3_All | Mucin-5AC-like isoform X2 | H. laboriosa | −4.45 | 1.39 |
| novel_mir63 | CL616.Contig1_All | Uncharacterized protein LOC113812248 | L. vannamei | −4.45 | 4.15 |
| novel_mir82 | CL2872.Contig1_All | Hypothetical protein C7M84_008734 | L. vannamei | −4.44 | 1.90 |
| novel_mir82 | CL348.Contig1_All | Caspase 4 | L. vannamei | −4.44 | 1.43 |
| novel_mir86 | CL5297.Contig3_All | Phospholipase D gamma 3-like | Hyalella azteca | 2.50 | −2.50 |
| Complement and coagulation cascades | |||||
| novel_mir63 | CL3345.Contig1_All | Mite allergen Der p 3-like | L. vannamei | −4.45 | 4.32 |
| novel_mir63 | CL3345.Contig2_All | Mite allergen Der p 3-like | L. vannamei | −4.45 | 5.60 |
| Peroxisome | |||||
| miR-210_4 | Unigene10280_All | Masquerade-like protein, partial | L. vannamei | −0.89 | 5.15 |
| novel_mir82 | Unigene18400_All | Copper/zinc superoxide dismutase isoform 5 | M. japonicus | −4.44 | 1.64 |
| novel_mir82 | Unigene5235_All | Indole-3-acetaldehyde oxidase-like | L. vannamei | −4.44 | 2.44 |
| NOD-like receptor signaling pathway | |||||
| novel_mir58 | CL1549.Contig1_All | Uncharacterized protein LOC113821210 | L. vannamei | −1.50 | 1.37 |
| novel_mir58 | CL1549.Contig3_All | Uncharacterized protein LOC113821210 | L. vannamei | −1.50 | 1.75 |
| novel_mir82 | CL348.Contig1_All | Caspase 4 | L. vannamei | −4.44 | 1.43 |
| PI3K-Akt signaling pathway | |||||
| novel_mir56 | CL1568.Contig5_All | Protein draper-like | L. vannamei | 4.21 | −3.48 |
| novel_mir58 | CL2943.Contig1_All | Transcription factor ATF-2 | L. vannamei | −1.50 | 1.34 |
| novel_mir58 | CL898.Contig9_All | Dentin sialophosphoprotein-like isoform X3 | L. vannamei | −1.50 | 4.30 |
| novel_mir86 | CL3368.Contig1_All | Vascular endothelial growth factor receptor precursor | L. vannamei | 2.50 | −2.11 |
| novel_mir86 | CL3963.Contig1_All | Collagen alpha-1(I) chain-like isoform X2 | H. azteca | 2.50 | −2.55 |
| MAPK signaling pathway | |||||
| novel_mir58 | CL1853.Contig1_All | Map kinase-interacting serine/threonine, partial | Procambarus clarkii | −1.50 | 2.46 |
| novel_mir58 | CL2943.Contig1_All | Transcription factor ATF-2 | L. vannamei | −1.50 | 1.34 |
| novel_mir86 | CL3368.Contig1_All | Vascular endothelial growth factor receptor precursor | L. vannamei | 2.50 | −2.11 |
| Lysosome | |||||
| miR-133-3p_2 | Unigene896_All | Glucosylceramidase-like | L. vannamei | −0.71 | 4.21 |
| novel_mir82 | CL1196.Contig2_All | Beta-hexosaminidase subunit alpha-like | L. vannamei | −4.44 | 3.11 |
| Necroptosis | |||||
| novel_mir63 | CL1469.Contig5_All | Von Willebrand factor A domain-containing protein 5A-like | L. vannamei | −4.45 | 1.85 |
| novel_mir82 | CL348.Contig1_All | Caspase 4 | L. vannamei | −4.44 | 1.43 |
| Apoptosis | |||||
| novel_mir63 | CL1469.Contig5_All | Von Willebrand factor A domain-containing protein 5A-like | L. vannamei | −4.45 | 1.85 |
| novel_mir82 | CL348.Contig1_All | Caspase 4 | L. vannamei | −4.44 | 1.43 |
| p53 signaling pathway | |||||
| novel_mir82 | CL348.Contig1_All | Caspase 4 | L. vannamei | −4.44 | 1.43 |
| Bacterial invasion of epithelial cells | |||||
| novel_mir40 | CL1405.Contig3_All | Leucine-rich repeat extensin-like protein 3 | L. vannamei | −1.20 | 2.85 |
| novel_mir63 | CL1405.Contig4_All | Leucine-rich repeat extensin-like protein 3 | L. vannamei | −4.45 | 4.03 |
| novel_mir56 | CL1610.Contig1_All | Paxillin-like | L. vannamei | 4.21 | −4.61 |
| novel_mir82 | CL3064.Contig1_All | Basic proline-rich protein-like, partial | Canis lupus dingo | −4.44 | 1.70 |
| Adherens junction | |||||
| novel_mir40 | CL1405.Contig3_All | Leucine-rich repeat extensin-like protein 3 | L. vannamei | −1.20 | 2.85 |
| novel_mir56 | CL4657.Contig5_All | Receptor-type tyrosine-protein phosphatase delta-like | L. vannamei | 4.21 | −1.28 |
| novel_mir63 | CL1405.Contig4_All | Leucine-rich repeat extensin-like protein 3 | L. vannamei | −4.45 | 4.03 |
| novel_mir82 | CL3064.Contig1_All | Basic proline-rich protein-like, partial | C. lupus dingo | −4.44 | 1.70 |
| C-type lectin receptor signaling pathway | |||||
| novel_mir82 | CL348.Contig1_All | Caspase 4 | L. vannamei | −4.44 | 1.43 |
| Retinol metabolism | |||||
| novel_mir63 | CL1418.Contig2_All | UDP-glucuronosyltransferase | L. vannamei | −4.45 | 2.75 |
| novel_mir63 | CL1418.Contig3_All | UDP-glucuronosyltransferase | L. vannamei | −4.45 | 3.05 |
| novel_mir63 | CL1418.Contig6_All | UDP-glucuronosyltransferase | L. vannamei | −4.45 | 3.41 |
| Ascorbate and aldarate metabolism | |||||
| novel_mir63 | CL1418.Contig2_All | UDP-glucuronosyltransferase | L. vannamei | −4.45 | 2.75 |
| novel_mir63 | CL1418.Contig3_All | UDP-glucuronosyltransferase | L. vannamei | −4.45 | 3.05 |
| novel_mir63 | CL1418.Contig6_All | UDP-glucuronosyltransferase | L. vannamei | −4.45 | 3.41 |
| Glycosaminoglycan biosynthesis—keratan sulfate | |||||
| novel_mir63 | CL427.Contig1_All | Alpha-(1,6)-fucosyltransferase-like | L. vannamei | −4.45 | 6.87 |
| novel_mir63 | CL427.Contig9_All | Alpha-(1,6)-fucosyltransferase-like | L. vannamei | −4.45 | 3.37 |
| Glycosaminoglycan biosynthesis—chondroitin sulfate/dermatan sulfate | |||||
| novel_mir82 | Unigene17220_All | Hypothetical protein C7M84_016157 | L. vannamei | −4.44 | 3.71 |
| Glycosaminoglycan biosynthesis—heparan sulfate/heparin | |||||
| novel_mir82 | Unigene17220_All | Hypothetical protein C7M84_016157 | L. vannamei | −4.44 | 3.71 |
| Glycosphingolipid biosynthesis—globo and isoglobo series | |||||
| novel_mir82 | CL1196.Contig2_All | Beta-hexosaminidase subunit alpha-like | L. vannamei | −4.44 | 3.11 |
| Glycosphingolipid biosynthesis—ganglio series | |||||
| novel_mir82 | CL1196.Contig2_All | Beta-hexosaminidase subunit alpha-like | L. vannamei | −4.44 | 3.11 |
DIV1, decapod iridescent virus 1.