Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 18;12:772926. doi: 10.3389/fphar.2021.772926

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Koshino, Nagano, Ota, Hyodo, Ueki, Komura, Sugimura-Nagata, Ebi, Ogasawara, Kasai, Hosokawa, Kasugai, Takahashi and Inaguma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

PBK enhanced the cellular proliferation of CRC cells. (A), exogenous PBK expression enhanced the cellular proliferation of CRC cells. Data are shown as mean ± S.D. *, p < 0.05, **, p < 0.01. (B), immunoblot analysis showing up-regulated P-ERK and PHH3 in PBK-induced CRC cells. (C), OTS514, a selective PBK inhibitor, suppressed the cellular proliferation of CRC cells. Data are shown as mean ± S.D. *, p < 0.05. (D), Annexin V assay in HCT116 and LoVo cell lines showing induction of apoptosis after OTS514 treatment. (E), protein expression of PHH3 and apoptosis-related proteins in CRC cells after OTS514 treatment. Note that BCL2 was expressed at under detectable levels in SW48 and HCT116. Bax expression was under detectable level in LoVo. Numbers below the immunoblot bands indicate relative expression.