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. 2022 Jan 18;12:772926. doi: 10.3389/fphar.2021.772926

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Copyright © 2022 Koshino, Nagano, Ota, Hyodo, Ueki, Komura, Sugimura-Nagata, Ebi, Ogasawara, Kasai, Hosokawa, Kasugai, Takahashi and Inaguma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PBK accumulated CDH1 of phosphorylated form and phosphorylated histone H3. A and B, immunoblot analysis showing PBK accumulated CDH1^cyt with phosphorylation. Note that the expression levels of co-transfected Luc were not affected by PBK. (C), in vitro kinase assay showing that both GST-tagged CDH1^cyt/WILD and CDH1^{cyt/S840,846,847A} were not phosphorylated by recombinant PBK (rPBK). In contrast, rHH3.1 was directly phosphorylated by rPBK (left panel). Immunoblot analysis showing CDH1^cyt/WILD and CDH1^{cyt/S840,846,847A} with or without kinase reaction. Note that no band shift was detected after kinase reaction (right panel). NS, non-specific.