Figure 5.

Mercaptopurine cumulative dose intensity and absolute neutrophil count in patients negative or positive for anti-asparaginase antibodies. Mercaptopurine cumulative dose intensity (DI; left y axes) and absolute neutrophil count (ANC) in cells/mm³ (right y axes) for continuation weeks 10-16 in patients who were negative or positive for anti-asparaginase antibodies against Elspar (T15) or Oncaspar (T16) measured at continuation week 7. Boxes and whiskers represent quartiles and non-outlier ranges. Nominal P values were *P<0.05; **P<0.01, ***P<0.001. There was a total of four comparisons, thus the Bonferroni significance threshold=0.01