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. 2021 Jan 7;107(2):403–416. doi: 10.3324/haematol.2020.259531

Figure 7.

Figure 7.

The combination of APR-246 with ferroptosis inducers has synergistic anti-leukemic effects in acute myeloid leukemia in vitro. (A) Viability curves for MOLM-14 and OCI-AML2 cells with or without GPX4 inducible small hairpin RNA (shRNA) at 16 hours (h) post APR-246 treatment. Prior to adding APR-246, the cells were treated for 2 days with doxycycline (n=3). Error bars ± standard deviation. (B) Illustrative synergy map (left panel) of 24 h co-treatment of MOLM-14 cells with APR-246 and RSL3. The mean cell viability of three independent experiments was used. Mean synergy scores of the most synergistic area of 24 h co-treatment of acute myeloid leukemia (AML) cell lines with APR-246 and RSL3 (n=3).(C) Illustrative synergy map (left panel) of 24 h co-treatment of MOLM-14 cells with APR-246 and FINO2. The mean cell viability of three independent experiments was used. Mean synergy scores of the most synergistic area of 24 h co-treatment of AML cell lines with APR-246 and FINO2 (n=3).