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. 2022 Jan 31;12(1):e049231. doi: 10.1136/bmjopen-2021-049231

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Flow chart of the participants. Maternal cortisol and maternal well-being were measured three times during pregnancy: in early pregnancy (<22 weeks), mid-pregnancy (22–36 weeks) and late pregnancy (≥36 weeks). The numbers indicate how many mothers participated at least once. Chorionic villus sampling (CVS), amniotic fluid and non-invasive prenatal testing (NIPT) were collected in early pregnancy. Maternal blood and partner blood were collected once during pregnancy. Majority donated blood in early or mid-pregnancy. AC, amniocentesis; CRHC, Care Register for Health Care; MBR, Medical Birth Register; MRR, Medical Reimbursement Register; PR, Population Register.