Table 3.

Primary and secondary outcomes

Variable	N	Inpatient n=695	Ambulatory, n=69		P value
			Ambulatory from diagnosis, n=15	Initially inpatient and then discharged to ambulatory, n=54
Primary outcome
Colectomy during index ASUC management period	764	15.0% (104/695)	13.3% (2/15)	13.0% (7/54)	0.95
Secondary outcomes
Admitted to hospital during treatment	764	99.9% (694/695)	40.0% (6/15)	100.0% (54/54)	0.0005
Corticosteroid therapy
Received intravenous corticosteroids
Yes	758	97.4% (672/690)	100.0% (15/15)	100.0% (53/53)	0.74
No (straight to biologic)		2.6% (18/690)	0.0% (0/15)	0.0% (0/53)
Type of intravenous corticosteroid
Hydrocortisone (intravenous)	740	87.6% (589/672)	20.0% (3/15)	79.2% (42/53)	0.0005
Methylprednisolone (intravenous)	740	12.4% (83/672)	80.0% (12/15)	20.8% (11/53)
Responded to corticosteroids	753	71.6% (490/684)	66.7% (10/15)	75.9% (41/54)	0.74
Rescue/primary induction therapy
Received rescue/primary induction therapy	751	40.9% (281/687)	60.0% (9/15)	36.7% (18/49)	0.28
Time to rescue/primary induction therapy (days)	286	6.0 (4.0–8.0)	3.5 (2.0–5.2)	5.0 (4.5–6.0)	0.19
Responded to rescue/primary induction treatment	301	80.4% (221/275)	62.5% (5/8)	88.9% (16/18)	0.26
Surgery
Time to colectomy (days)	112	12.0 (7.0–21.0)	16.0 (14.0–43.5)	6.0 (3.5–13.0)	0.15
Mortality	754	1.2% (8/686)	0.0% (0/15)	0.0% (0/53)	1
Duration of hospital treatment (days)*	695	7.0 (5.0–13.0)	6.0 (6.0–18.0)	7.0 (5.0–9.0)	0.47

P value=Fisher’s exact test or Kruskal-Wallis test for discrete and continuous variables continuous, respectively. Discrete variables displayed % (n/N) and continuous variables median (IQR).

*Only patients with ambulatory care from diagnosis who were admitted to hospital (n=6) had inpatient stay data captured.

ASUC, acute severe ulcerative colitis.