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. 2022 Jan 31;12(1):e054296. doi: 10.1136/bmjopen-2021-054296

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Flow diagram of study visits and assessments. ^aMINI-Kid diagnostic interview administered by phone with the participant and parent present. ^bScreening and study visits may be conducted virtually according to patient preference and current COVID-19 restrictions. ^cHeight, weight and blood pressure will be determined either on-site or by a participant’s regular care provider. ^dParticipants will inform study staff of the date and time of their first dose. Weekly reminders regarding adherence and completion of the participant e-diary as required will be sent via email, phone or text according to participant preference and consent. CY-BOCS, Children’s Yale-Brown Obsessive Compulsive Scale; BCCH, British Columbia Children’s Hospital; CGI, Clinical Global Impression; PANDAS, paediatric autoimmune neuropsychiatric disorder associated with streptococcal infections; PANS, paediatric acute-onset neuropsychiatric syndrome; PGI, Patient/Parent Global Impression; PPQ, Participant Perspective Questionnaire.