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. 2022 Jan 24;10(1):e002579. doi: 10.1136/bmjdrc-2021-002579

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Comparison and correlation analyses of serum levels of MDA, Hsp90α, Hsp90β, WCC, and CRP in the study subjects. Serum MDA (A), Hsp90α (B), and Hsp90β (C) levels were measured in the different groups. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001 versus the DM or the DLEAD group. Correlation between Hsp90α (D–F) and Hsp90β (G–I) and WCC, CRP, and MDA levels in serum samples. Pearson’s coefficient tests were conducted to calculate statistical significance. CRP, C reactive protein; DCLI, diabetic critical limb ischemia; DLEAD, diabetic lower extremity arterial disease; DM, diabetes mellitus; Hsp90, heat shock protein 90; MDA, malondialdehyd; WCC, white cell count.