Table 3.
Top 20 Clusters With Their Representative Enriched Terms (One per Cluster) a .
| GO | Category | Description | Count | % | Log10(P) | Log10(q) |
|---|---|---|---|---|---|---|
| R-HSA-1632852 | Reactome Gene Sets | Macroautophagy | 39 | 61.90 | −81.53 | −77.21 |
| hsa04140 | KEGG Pathway | Autophagy-animal | 39 | 61.90 | −74.40 | −70.78 |
| hsa04137 | KEGG Pathway | Mitophagy-animal | 19 | 30.16 | −34.35 | −31.20 |
| GO:0061912 | GO Biological Processes | Selective autophagy | 14 | 22.22 | −24.90 | −21.87 |
| GO:0042594 | GO Biological Processes | Response to starvation | 19 | 30.16 | −24.68 | −21.66 |
| R-HSA-5205647 | Reactome Gene Sets | Mitophagy | 12 | 19.05 | −23.79 | −20.81 |
| hsa04621 | KEGG Pathway | NOD-like receptor signaling pathway | 14 | 22.22 | −16.93 | −14.17 |
| R-HSA-168928 | Reactome Gene Sets | DDX58/IFIH1-mediated induction of interferon-α/β | 11 | 17.46 | −15.99 | −13.24 |
| CORUM:6472 | CORUM | Bcl-2-Beclin1-UVRAG-PI(3)KC3 complex | 5 | 7.94 | −12.99 | −10.27 |
| GO:0007249 | GO Biological Processes | I-kappaB kinase/NF-kappaB signaling | 12 | 19.05 | −11.34 | −8.66 |
| R-HSA-5689896 | Reactome Gene Sets | Ovarian tumor domain proteases | 7 | 11.11 | −11.16 | −8.50 |
| M121 | Canonical Pathways | PID MTOR 4PATHWAY | 8 | 12.70 | −11.00 | −8.35 |
| CORUM:6232 | CORUM | ULK1-ATG13-RB1CC1-ATG101 complex | 4 | 6.35 | −10.38 | −7.77 |
| CORUM:6816 | CORUM | ULK1-ATG13-ATG14-PIK3C3 complex | 4 | 6.35 | −10.38 | −7.77 |
| GO:0075044 | GO Biological Processes | Autophagy of host cells involved in interaction with symbiont | 4 | 6.35 | −9.68 | −7.13 |
| GO:0010942 | GO Biological Processes | Positive regulation of cell death | 15 | 23.81 | −9.36 | −6.82 |
| R-HSA-8854214 | Reactome Gene Sets | TBC/RABGAPs | 6 | 9.52 | −8.67 | −6.22 |
| GO:0051403 | GO Biological Processes | Stress-activated MAPK cascade | 10 | 15.87 | −8.44 | −5.99 |
| hsa04064 | KEGG Pathway | NF-kappa B signaling pathway | 7 | 11.11 | −8.27 | −5.87 |
| GO:2000378 | GO Biological Processes | Negative regulation of reactive oxygen species metabolic process | 6 | 9.52 | −7.78 | −5.47 |
a
“Count” is the number of genes in the user-provided lists with membership in the given ontology term. “%” is the percentage of all of the user-provided genes that are found in the given ontology term. “Log10(P)” is the P value in log base 10. “Log10(q)” is the multi-test adjusted P value in log base 10.