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. 2019 Nov 16;13(2 Suppl):898S–907S. doi: 10.1177/1947603519888787

Figure 5.

Figure 5.

Effects of miR-140-5p on abnormal metabolic dysfunction and inflammatory responses in the osteoarthritis (OA) chondrocyte model mediated by LINC01534. (A) Effect of miR-140-5p inhibitor on the mRNA expression of miR-140-5p in chondrocytes. (B) Effect of miR-140-5p inhibitor on the mRNA expressions of aggrecan and collagen II in chondrocytes. (C) The effect of miR-140-5p inhibitor on the mRNA expressions of matrix metalloproteinase–3 (MMP-3), MMP-9, and MMP-13 in chondrocytes. (D) Effect of miR-140-5p inhibitor on MMP-3 and MMP-13 contents in the supernatant of chondrocytes. (E) Effect of miR-140-5p inhibitor on MMP-9 content in the supernatant of chondrocytes. (F-I) Effect of miR-140-5p inhibitor on the contents of prostaglandin E2 (PGE2; F), NO (G), interleukin-6 (IL-6; H), IL-8, and tumor necrosis factor–α (TNF-α; I) in the supernatant of chondrocytes. *P < 0.05, #P < 0.05.