Figure 1.

Intra-articular injection of integrin α10-selected mesenchymal stromal cells (MSCs) following acute injury results in long-term changes in gene expression of the synovial membrane including (A) increased expression of CCL5, (B) decreased expression of TIMP2, and (C) decreased expression of NF-κB. Data are expressed as log₂ transformed gene counts relative to 3 housekeeping genes (GAPHD, HPRT1, UBC) detected using NanoString. Data are represented as single datapoints, with box-and-whiskers plot indicating median with interquartile range (n = 7 in each group) (*P < 0.05, paired t test). HG = housekeeping genes.