Table 2.

Top 20 Significantly Upregulated and Downregulated Genes in FMK and OPH Samples.

FMK-UP		OPH-UP		FMK-DOWN		OPH-DOWN
Gene	Fold Change	Gene	Fold Change	Gene	Fold Change	Gene	Fold Change
Ccl5	87.96	Ccl5	51.90	Tyrobp	−50.06	Mrc1	−10.53
Plac8	62.56	Plac8	34.23	Laptm5	−37.85	Adgre1	−10.04
Cxcl10	43.30	Cxcl10	32.77	Adgre1	−37.47	Tyrobp	−8.47
Ifi44	34.85	Ifi44	29.71	Lcp1	−34.18	Trem2	−8.08
Usp18	30.79	Usp18	27.17	Msr1	−33.00	Cyth4	−7.27
Isg15	28.24	Cxcl9	24.57	Csf1r	−32.16	Cd68	−7.07
Irf7	27.35	Gbp3	24.56	Nckap1	−26.79	Slc37a2	−7.03
Gbp3	25.68	Ifit1	22.56	Fyb	−24.34	Mmp9	−7.01
Ifit1	23.57	Isg15	22.18	Trem2	−23.95	Hpgds	−6.98
Ifih1	23.37	Irf7	21.56	Hpgds	−21.50	Ms4a7	−6.61
Mx1	21.92	H2-Q4	20.57	Ms4a7	−21.48	Slc7a8	−6.50
Cxcl9	21.39	Ifih1	19.64	Ctss	−19.24	Csf1r	−6.37
H2-Q4	19.70	Mx1	18.25	Clec4a2	−18.09	Fermt3	−6.34
Oas1b	19.63	Oas1b	18.21	Spi1	−16.90	Fyb	−6.14
Rsad2	18.34	Rsad2	17.16	Ptpn6	−16.71	Fcgr2b	−6.12
Zbp1	17.19	Oasl2	14.61	C1qa	−16.46	Vav1	−6.12
Herc6	17.11	Herc6	13.98	Fermt3	−15.18	Lcp1	−6.03
Gbp2	15.83	Ecel1	13.11	Myo1f	−14.72	Pf4	−5.96
Oasl2	15.60	Gbp2	12.95	Coro1a	−14.37	Pik3cg	−5.94
Gbp9	15.01	Tap1	12.34	Igsf6	−13.87	Nckap1l	−5.79

FMK UP = genes upregulated after FMK inhibitor; FMK DOWN = genes downregulated after FMK inhibitor; OPH UP = genes upregulated after OPH inhibitor; OPH DOWN = genes downregulated after OPH inhibitor.

Bold—affected by both inhibitors (FMK and OPH) and being related to OA. Fold changes are included in the right columns. The complete list of upregulated and downregulated genes including fold changes is in Supplementary File 1.