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. 2021 Jul 3;24(2):213–225. doi: 10.1093/neuonc/noab159

Fig. 5.

Fig. 5

Preventive vs therapeutic schedules. (A) Longitudinal intravital multiphoton microscopy investigating GNE-317 treatment in preventive and treatment schedules in A2058 and H1 melanoma models. (B) Different doses of GNE-317 and their impact on blood glucose levels in mice intracardially injected with A2058 melanoma cells, n = 10 measurements in n = 5 mice. (C) Individual volumes of metastases that mastered all steps of metastatic cascade were measured at day 28. A2058 cells, intravital multiphoton microscopy, n = 111/97/31/20 cells in n = 3 mice per group, error bars show SEM, Mann-Whitney test. H1 melanoma cells, intravital multiphoton microscopy, n = 120/64/26 cells in 3/3/4 mice per group, error bars show SEM, Mann-Whitney test. (D) Representative intravital multiphoton microscopy images visualize A2058 BM growth among groups. (E) Quantification of BM volume gain is indicated for all four groups and observation periods. Volume of BM was normalized to volume at day 3. A2058 melanoma cells, intravital multiphoton microscopy, n = 179/175/205/109 cells in n = 3 mice per group, error bars show SD, Student’s t test.