Table 1.

Summary Mendelian Randomization Analysis Using LTL-Associated Variants and Glioma GWAS Data

Locus	SNP	Proximal Gene	P Glioma	P LTL	P SMR	qSMR	P HEIDI
5p15	rs7705526	TERT	5.01 × 10−61	5.34 × 10−45	9.80 × 10−27	1.86 × 10−25	1.71 × 10−3
5p15	rs2853677	TERT	1.08 × 10−28	3.35 × 10−31	9.68 × 10−16	9.20 × 10−15	3.88 × 10−8
3q26	rs10936600	TERC	5.34 × 10−6	7.18 × 10−51	1.33 × 10−5	8.42 × 10−5	.871
20q13	rs34978822	RTEL1	1.12 × 10−8	7.26 × 10−10	2.81 × 10−5	1.34 × 10−4	7.86 × 10−8
10q24	rs9419958	STN1(OBFC1)	4.15 × 10−6	5.05 × 10−19	4.31 × 10−5	1.64 × 10−4	.160
20q13	rs75691080	RTEL1/STMN3	2.67 × 10−5	5.99 × 10−14	2.47 × 10−4	7.82 × 10−4	3.21 × 10−3
11q22	rs228595	ATM	4.09 × 10−5	1.43 × 10−8	8.89 × 10−4	2.41 × 10−3	2.56 × 10−3
6p22	rs34991172	CARMIL1	1.55 × 10−3	6.19 × 10−9	5.45 × 10−3	1.29 × 10−2	.829
7q31	rs59294613	POT1	3.46 × 10−3	1.17 × 10−13	6.52 × 10−3	1.38 × 10−2	.767
6p21	rs2736176	PRRC2A	4.57 × 10−3	3.53 × 10−10	9.76 × 10−3	1.85 × 10−2	.449
1q42	rs2255403	PARP1	8.92 × 10−3	1.72 × 10−10	1.55 × 10−2	2.68 × 10−2	.711
14q24	rs2302588	DCAF4	3.09 × 10−2	1.68 × 10−8	4.38 × 10−2	.069	.409
4q32	rs4691895	NAF1	.089	1.58 × 10−21	.095	.139	.291
20q13	rs73624724	RTEL1/ZBTB46	.138	6.33 × 10−12	.147	.200	2.35 × 10−6
16q23	rs62053580	RFWD3	.164	4.06 × 10−8	.178	.225	.139
16q22	rs3785074	TERF2	.241	4.64 × 10−10	.249	.278	.750
4q13	rs13137667	MOB1B	.228	2.43 × 10−8	.240	.285	.335
16q23	rs7194734	MPHOSPH6	.594	6.94 × 10−10	.596	.596	.494
19p12	rs8105767	ZNF208	.563	5.42 × 10−13	.565	.596	.430

Abbreviations: GWAS, genome-wide association studies; HEIDI, heterogeneity in dependent instruments; LTL, leukocyte telomere length; SMR, summary Mendelian randomization.

P _LTL published P-value.¹³ Complete results are detailed in Supplementary Table 6.