Table 2.
Relationship Between Gene Expression (Whole Blood e-QTL) With Leukocyte Telomere Length (LTL) SNPsa
| LTL Locus | Proximal Gene | SNP | P LTL | P eQTL | P SMR | qSMR | P HEIDI |
|---|---|---|---|---|---|---|---|
| 6p21 | HSPA1A | rs494620 | 1.28 × 10−6 | 1.40 × 10−74 | 2.85 × 10−6 | 1.12 × 10−4 | 1.63 × 10−3 |
| 20q13 | STMN3 | rs3865523 | 3.63 × 10−7 | 2.49 × 10−34 | 2.64 × 10−6 | 1.56 × 10−4 | 7.20 × 10−5 |
| 6p21 | IER3 | rs2233980 | 6.19 × 10−7 | 2.05 × 10−60 | 1.85 × 10−6 | 2.18 × 10−4 | .030 |
| 6p21 | FLOT1 | rs3130985 | 2.67 × 10−6 | 6.93 × 10−37 | 1.07 × 10−5 | 3.15 × 10−4 | .029 |
| 10q24 | SLK | rs10883954 | 9.18 × 10−6 | 2.29 × 10−25 | 4.49 × 10−5 | 5.89 × 10−4 | .011 |
| 6p22 | BTN3A2 | rs9393710 | 2.33 × 10−5 | 9.06 × 10−237 | 2.72 × 10−5 | 6.42 × 10−4 | 7.79 × 10−3 |
| 6p21 | HLA-C | rs2523578 | 2.63 × 10−5 | 1.55 × 10−65 | 4.47 × 10−5 | 6.59 × 10−4 | .012 |
| 6p21 | HCP5 | rs2596495 | 7.39 × 10−7 | 5.73 × 10−14 | 3.56 × 10−5 | 7.00 × 10−4 | 1.62 × 10−3 |
| 11q22 | NPAT | rs228601 | 3.38 × 10−7 | 5.93 × 10−12 | 4.17 × 10−5 | 7.03 × 10−4 | .236 |
| 10q24 | SLK | rs7076157 | 1.05 × 10−5 | 8.50 × 10−22 | 6.21 × 10−5 | 7.33 × 10−4 | 1.75 × 10−3 |
| 6p21 | LY6G5C | rs1144708 | 1.86 × 10−5 | 2.25 × 10−24 | 7.91 × 10−5 | 8.49 × 10−4 | 2.01 × 10−4 |
| 20q13 | LIME1 | rs6062509 | 8.71 × 10−5 | 2.89 × 10−65 | 1.31 × 10−4 | 1.29 × 10−3 | .014 |
| 6p21 | RNF5 | rs192471087 | 6.88 × 10−5 | 2.49 × 10−37 | 1.45 × 10−4 | 1.31 × 10−3 | .338 |
| 6p22 | BTN2A1 | rs3734544 | 1.62 × 10−4 | 3.34 × 10−189 | 1.83 × 10−4 | 1.54 × 10−3 | 3.49 × 10−3 |
| 6p21 | NEU1 | rs3117573 | 9.82 × 10−6 | 1.75 × 10−8 | 5.05 × 10−4 | 3.97 × 10−3 | .473 |
| 20q13 | UCKL1 | rs111319089 | 6.79 × 10−4 | 2.53 × 10−28 | 1.16 × 10−3 | 8.58 × 10−3 | .169 |
| 6p21 | PBX2 | rs114544105 | 3.62 × 10−4 | 1.29 × 10−9 | 2.11 × 10−3 | 1.46 × 10−2 | .163 |
| 10q24 | ITPRIP | rs34970111 | 1.99 × 10−3 | 3.70 × 10−30 | 2.84 × 10−3 | 1.86 × 10−2 | .193 |
| 11q22 | ACAT1 | rs35188041 | 3.23 × 10−3 | 1.49 × 10−145 | 3.43 × 10−3 | 2.13 × 10−2 | 5.51 × 10−3 |
| 5p15 | ZDHHC11 | rs56007868 | 3.45 × 10−3 | 1.60 × 10−12 | 6.88 × 10−3 | 4.06 × 10−2 | .812 |
| 3q26 | GPR160 | rs2160901 | 7.64 × 10−3 | 1.43 × 10−119 | 8.04 × 10−3 | 4.31 × 10−2 | .584 |
| 6p22 | BTN3A2 | rs9379862 | 7.55 × 10−3 | 3.08 × 10−255 | 7.74 × 10−3 | 4.35 × 10−2 | 1.59 × 10−3 |
| 1q42 | PARP1 | rs12240196 | 7.60 × 10−3 | 2.09 × 10−54 | 8.52 × 10−3 | 4.37 × 10−2 | .127 |
| 20q13 | LKAAEAR1 | rs7271530 | 8.20 × 10−3 | 8.51 × 10−30 | 1.00 × 10−2 | 4.93 × 10−2 | .805 |
Abbreviations: e-QTL, expression quantitative trait loci; HEIDI, heterogeneity in dependent instruments; SMR, summary Mendelian randomization.
aAnalysis +/− 1 Mb around LTL SNPs. Only significant e-QTL probes (FDR q ≤ .05) are shown.
Complete results are detailed in Supplementary Table 9.