Table 3.
Relationship Between Gene Expression (Brain e-QTL) With Leukocyte Telomere Length (LTL) SNPsa
| LTL Locus | Proximal Gene | SNP | P LTL | P eQTL | P SMR | qSMR | P HEIDI |
|---|---|---|---|---|---|---|---|
| 6p21 | BAG6 | rs2523593 | 4.28 × 10−7 | 2.14 × 10−287 | 5.51 × 10−7 | 5.95 × 10−5 | .011 |
| 6p21 | C4A | rs501942 | 4.90 × 10−6 | 9.49 × 10−48 | 1.31 × 10−5 | 4.72 × 10−4 | 4.65 × 10−3 |
| 6p22 | BTN3A2 | rs9366653 | 8.34 × 10−6 | <1 × 10−302 | 9.59 × 10−6 | 5.18 × 10−4 | 4.92 × 10−4 |
| 6p21 | FLOT1 | rs2596495 | 7.39 × 10−7 | 4.53 × 10−17 | 2.00 × 10−5 | 5.40 × 10−4 | .133 |
| 6p21 | CCHCR1 | rs2523593 | 4.28 × 10−7 | 1.13 × 10−10 | 6.92 × 10−5 | 1.50 × 10−3 | 2.94 × 10−3 |
| 11q22 | ATM | rs10890822 | 4.22 × 10−7 | 1.71 × 10−9 | 1.07 × 10−4 | 1.93 × 10−3 | 6.11 × 10−4 |
| 6p21 | CYP21A1P | rs6463 | 1.30 × 10−5 | 2.92 × 10−13 | 1.82 × 10−4 | 2.81 × 10−3 | .362 |
| 6p22 | BTN3A3 | rs13220495 | 2.29 × 10−5 | 5.56 × 10−13 | 2.61 × 10−4 | 3.52 × 10−3 | .079 |
| 20q13 | ZBTB46 | rs6011149 | 5.80 × 10−5 | 6.21 × 10−15 | 3.52 × 10−4 | 4.22 × 10−3 | 3.32 × 10−4 |
| 6p21 | DDAH2 | rs1144708 | 1.86 × 10−5 | 4.64 × 10−10 | 4.18 × 10−4 | 4.51 × 10−3 | .039 |
| 6p21 | VARS2 | rs2507989 | 6.69 × 10−4 | 1.26 × 10−17 | 1.57 × 10−3 | 1.54 × 10−2 | .227 |
| 3q26 | AC008040.1 | rs13315158 | 2.96 × 10−4 | 3.03 × 10−8 | 2.45 × 103 | 2.20 × 102 | .435 |
| 10q24 | STN1 | rs3850670 | 5.55 × 10−4 | 8.50 × 10−9 | 3.06 × 10−3 | 2.55 × 10−2 | .021 |
| 20q13 | STMN3 | rs6011016 | 1.40 × 10−3 | 1.74 × 10−10 | 4.28 × 10−3 | 3.30 × 10−2 | .230 |
| 10q24 | GSTO2 | rs276203 | 6.59 × 10−3 | <1 × 10−302 | 6.71 × 10−3 | 4.83 × 10−2 | .494 |
Abbreviations: e-QTL, expression quantitative trait loci; HEIDI, heterogeneity in dependent instruments; SMR, summary Mendelian randomization.
aAnalysis +/− 1 Mb around LTL SNPs. Only significant e-QTL probes (FDR q ≤ .05) are shown.
Complete results are detailed in Supplementary Table 10.