Figure 3. Shortening of clotting time of polyP70-GNPs in human plasma when assayed for contact activation as a function of monoP and GNP concentration.
A: Reduction in clotting time of 10nm polyP70-GNPs and 50nm polyP70-GNPs compared to equivalent concentration of molecularly dissolved polyP70 and heterogeneous long-chain polyP800. B: Reduction of clotting time of 10nm polyP70-GNPs compared to the equivalent concentration of 10nm bulk-GNPs and 10nm PEG-GNPs. C: Shortenting of clotting time of 50nm polyP70-GNPs compared against the same concentration of 50nm bulk-GNPs and 50nm PEG-GNPs.