. Author manuscript; available in PMC: 2022 Feb 5.

Published in final edited form as: Lancet Healthy Longev. 2022 Jan 5;3(1):e42–e53. doi: 10.1016/s2666-7568(21)00283-x

Table 5:

Adjusted HRs of SBP and PP variation for cognitive loss, mild cognitive impairment, and probable dementia

	Adjusted HR (95% CI)^*	p value
CV of systolic blood pressure

Cognitive loss	1·10 (1·04–1·17)	0·0009
Mild cognitive impairment	1·10 (1·03–1·18)	0·005
Probable dementia	1·07 (0·98–1·16)	0·14

CV of pulse pressure

Cognitive loss	1·02 (0·99–1·06)	0·27
Mild cognitive impairment	1·02 (0·98–1·07)	0·27
Probable dementia	1·01 (0·96–1·06)	0·68

Cognitive loss was the combined endpoint of either mild cognitive impairment or probable dementia, or both. HR was estimated based on every 5-rise of CV (ie, estimated CV/5) associated with cognitive impairment, mild cognitive impairment, and probable dementia. BMI=body-mass index. CV=coefficient of variation. HR=hazard ratio. PP=pulse pressure. SBP=systolic blood pressure.

Adjusted for age, race and ethnicity, hormone therapy, in the WHI HT trial, education, health insurance, BMI, smoking status, alcohol consumption, physical activity, anti-hyperlipidaemic medication use, and diabetes.