Table 3. Strength of Associations Between EYO and Main Cognitive and Tau Outcomes in Each Groupa.
| NC | pMC Val66 | pMC Met66 | sMC Val66 | sMC Met66 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| β (SE) | P value | β (SE) | P value | β (SE) | P value | β (SE) | P value | β (SE) | P value | |
| Episodic memory | −0.108 (0.055) | .05 | −0.156 (0.091) | .10 | −0.580 (0.134) | <.001 | −0.478 (0.211) | .02 | −0.053 (0.342) | .88 |
| Global cognition | −0.043 (0.056) | .45 | −0.147 (0.094) | .12 | −0.240 (0.138) | .08 | −0.726 (0.217) | <.001 | −1.584 (0.344) | <.001 |
| p-Tau217/tau217 (%) | 0.012 (0.045) | .79 | 0.410 (0.076) | <.001 | 0.770 (0.111) | <.001 | 0.945 (0.175) | <.001 | 0.105 (0.278) | .71 |
| p-Tau205/tau205 (%) | 0.039 (0.046) | .41 | 0.570 (0.078) | <.001 | 0.469 (0.115) | <.001 | 0.659 (0.180) | <.001 | −0.731 (0.286) | .01 |
Abbreviations: CDR, Clinical Dementia Rating; EYO, estimated year of symptom onset; NC, mutation noncarrier; pMC, presymptomatic (CDR 0) mutation carrier; p-tau, phosphorylated tau; sMC, symptomatic (CDR ≥0.5) mutation carrier.
a
All β estimates have been standardized.