Table 1.
General data, sleep quality, emotion, cognition, T/S ratio, and sNfL.
| Item | CID (n = 80) | HCs (n = 51) | Statistic | P |
|---|---|---|---|---|
| Age, y | 48.900 ± 10.416 | 47.392 ± 10.088 | t = 0.818 | .415 |
| BMI, kg/m2 | 23.519 ± 3.404 | 23.588 ± 2.957 | t = −0.119 | .905 |
| PSQI score | 14 (13, 16) | 0 (0, 2) | U = 0.000 | <.001 |
| ISI score | 14 (11, 17) | 0 (0, 0) | U = 0.000 | <.001 |
| HAMA-14 score | 12 (8, 16.75) | 1 (1, 2) | U = 34.500 | <.001 |
| HAMD-17 score | 10 (7, 14) | 1 (0, 2) | U = 16.5000 | <.001 |
| MoCA score | 18 (15, 22) | 23 (20, 26) | U = 1094.000 | <.001 |
| T/S ratio | 1.313 ± 0.430 | 2.672 ± 0.373 | t = −18.540 | <.001 |
| sNfL, pg/mL | 72.220 ± 22.763 | 48.456 ± 10.775 | t = 6.967 | <.001 |
Normally distributed variables are expressed as means ± SDs; non–normally distributed variables are expressed as 50th (25th, 75th) percentiles. BMI = body mass index, CID = chronic insomnia disorder, HAMA-14 = Hamilton Anxiety Scale (14 items), HAMD-17 = Hamilton Depression Rating Scale (17 items), HC = healthy control, ISI = Insomnia Severity Index, MoCA = Montreal Cognitive Assessment, PSQI = Pittsburgh Sleep Quality Index, sNfL = serum neurofilament light chain, T/S ratio = relative telomere repeat copy/single-copy gene ratio.