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. 2022 Feb 1;13(1):e03044-21. doi: 10.1128/mbio.03044-21

FIG 4.

FIG 4

Pathological analysis of hamster lungs. Representative histopathological images of the lungs of hamsters that were mock-infected (panels D, H, L) or intranasally inoculated with 1,000 PFU of SARS-CoV-2 (day 0) and co-administered favipiravir (300 mg/kg) and GS-441524 (25 mg/kg) as a prophylactic (days –1 to 3; twice/day) (panels A, E, I) or therapeutic regimen (days 1 to 3; twice/day) (panels B, F, J), or vehicle control (panels C, G, K). The lungs were analyzed on day 4 postinfection. (E to H) In situ hybridization for SARS-CoV-2 viral RNA detection. (I to L) Immunohistochemistry for SARS-CoV-2 viral antigen nucleocapsid protein detection. Panels A to D: scale bar = 500 μm. Panels E to G: scale bar = 100 μm. Panels I to L: scale bar = 20 μm.