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. 2022 Feb 1;13(1):e03044-21. doi: 10.1128/mbio.03044-21

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Copyright © 2022 Chiba et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 5 — Inhibitory effects of GS-441524 and/or favipiravir on SARS-CoV-2 airborne transmission between hamsters. (A, B) Timeline (panel A) and scheme (panel B) of transmission study. Naive hamsters (exposed animals) were administered favipiravir (300 mg/kg) and/or GS-441524 (25 mg/kg) or vehicle control (days –1 to 3 post-exposure; twice/day; n = 6/group). Another group of animals (infected animals) was inoculated with 1,000 PFU of SARS-CoV-2 Spike-D614G variant. One day after the exposed animals began their treatment regimen, each exposed animal was paired with one of the infected animals with a 5-cm gap between their cages. Organs were harvested for virus titration on day 4 postinfection or day 4 post-exposure from infected or exposed animals, respectively. (C) Infectious virus titers (PFU/g) in the nasal turbinate and lungs on day 4 post-exposure (upper panel) or day 4 postinfection (lower panel) were examined by performing plaque assays. ND, not detected (limit of detection: 10 PFU/organ).