Table 1. Average MSE and PSNR calculated with respect to simulated noiseless data.

The first column shows the intensity factor used when Poisson sampling normalized data. The second column is relative to the average metrics calculated for noisy patterns at the correspondent intensity factor. The last two columns report the average performance of the two methods.

	Average noisy pattern		Average U-Net		Average binary filter
Intensity factor	MSE	PSNR	MSE	PSNR	MSE	PSNR
1000	3.8 × 10−6	54.2	8.5 × 10−7	60.7	3.5 × 10−7	64.6
500	7.6 × 10−6	51.2	1.4 × 10−6	58.5	6.8 × 10−7	61.7
100	3.7 × 10−5	44.3	3.0 × 10−6	55.2	2.8 × 10−6	55.5
50	7.4 × 10−5	41.3	5.9 × 10−6	52.3	5.0 × 10−6	53.0
10	3.8 × 10−4	34.2	1.2 × 10−5	49.2	2.1 × 10−5	46.7