Figure 13.

The initial pressor response to ArcN AngII in pregnant rats is mediated by increased vasopressin secretion. A, Grouped time course data from pregnant rats showing that the initial, rapid increase in MAP triggered by ArcN AngII nanoinjections 15 min after intraperitoneal saline (gray circles; n = 6) are abolished 15 min after intraperitoneal injections of the AVP type 1 receptor antagonist (AVP1x; closed black squares; n = 6). Another group of control pregnant rats received ArcN aCSF 15 min after intraperitoneal AVP1x (open triangles; n = 5). B, Statistical comparison of data obtained at baseline (time 0), 15 min after intraperitoneal saline or AVP1x, as well as the maximum changes between 15 and 25 min (time 25 min) and the maximum changes between 95 and 105 min (time 105 min) after injecting AngII into the ArcN; *compared with time 0; †between groups at the same time. Error bars represent SEM.