Table 3.
Groups | Liver | Kidney | |||
---|---|---|---|---|---|
ALT (U/L) | AST (U/L) | Total bilirubin (mg/dl) | BUN (mg/dl) | Creatinine (mg/dl) | |
Normal control | 20.8 ± 1.0abcd | 21.9 ± 1.5abcd | 0.38 ± 0.0c | 18.8 ± 0.7abcd | 0.35 ± 0.02ns |
Diabetic control | 55.4 ± 3.8abcf | 79.1 ± 3.5abcdf | 1.3 ± 0.06c | 38.2 ± 2.0af | 1.5 ± 0.05ns |
Glibenclamide 10mg/kg | 25.8 ± 2.9bcdf | 28.5 ± 2.2bcdf | 0.42 ± 0.03c | 22.4 ± 2.0bcdf | 0.62 ± 0.02ns |
HyL 200mg/kg | 29.8 ± 2.2abcdf | 39.5 ± 2.8acdf | 0.61 ± 0.06c | 28.1 ± 2.6abcdf | 0.70 ± 0.07ns |
HyL 100mg/kg | 35.6 ± 3.1abcdf | 47.3 ± 3.2abcdf | 0.89 ± 0.03c | 30.2 ± 3.2abcdf | 0.95 ± 0.08ns |
HyL 50mg/kg | 45.3 ± 4.4acdf | 59.3 ± 3.8abdf | 0.96 ± 0.04ns | 32.6 ± 2.8acdf | 1.12 ± 0.09ns |
SoL 200mg/kg | 45.2 ± 1.5acdf | 42.6 ± 2.8acdf | 0.85 ± 0.03c | 35.5 ± 2.3adf | 1.23 ± 0.09ns |
SoL 100mg/kg | 50.3 ± 4.6abdf | 60.3 ± 3.7abdf | 0.99 ± 0.07ns | 38.2 ± 3.1af | 1.36 ± 0.26ns |
SoL 50mg/kg | 55.3 ± 5.1abcf | 72.3 ± 4.9abcf | 1.32 ± 0.09c | 40.2 ± 4.2abf | 1.49 ± 0.34ns |
Values expressed as means (n = 7) ± SD with *p < 0.05 in comparison with Glibenclamide representing “a”, SoL 200 mg/kg representing “b”, SoL 100 mg/kg representing “c”, SoL 50 mg/kg representing “d”, diabetic control representing “e” and normal control representing “f” with all respective concentrations of HyL and controls. “ns” represent non significance