Table 2.
Interaction scheme between PLpro inhibitor binding site amino acid residues and ligands (X depicts the presence of interaction)
|
Aminoacid residue |
GRL 0617 |
Epicriptine |
Methergoline |
Ergometrine |
|---|---|---|---|---|
|
ASP164 |
X |
X |
X |
X |
|
GLN269 |
X |
X |
X |
|
|
GLU167 |
|
X |
|
X |
|
GLY163 |
|
X |
|
|
|
LEU162 |
X |
|
|
|
|
MET208 |
|
X |
|
|
|
PRO247 |
X |
X |
|
|
|
PRO248 |
X |
X |
X |
|
|
TYR264 |
X |
X |
X |
X |
|
TYR268 |
X |
|
X |
X |
|
TYR273 |
X |
|
|
X |