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. 2022 Feb 1;20:45. doi: 10.1186/s12916-022-02250-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Change of Montreal Cognitive Assessment (MoCA) score over time. Patients were grouped by whether they were prescribed neural network treatment of choice (NNToC) according to the Long Short Term Memory (LSTM) model. The X-axis represents the duration of taking a particular medication, where x = 0 means the treatment initiation time. Data shown are mean values, with error bars indicating standard deviation. External validation on Oxford Health NHS Foundation Trust (OHFT). One hundred sixty [14.20%] patients were prescribed NNToC and reported a smaller MoCA reduction after 1.75 years compared to the 967 [85.80%] patients who were not (1.03 [0.19] vs 1.56 [0.21], respectively; P = 0.09). A detailed quantitative report of score changes is provided in Additional file 1: Table S5