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. 2022 Feb 1;19:8. doi: 10.1186/s12979-022-00264-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Effect of ACA, Rapa and 17aE2 treatments on liver MEK3 and p38MAPK signaling in liver. A Representative western blots for phospho-MEK3 at Ser189 (pMEK3) and total levels of MEK3 protein as well as phosphor-p38MAPK at Threonine 180 (p-p38) and p38 protein levels in liver samples from young untreated (Y), old untreated (O), old treated with ACA or Rapa (O, early and late treatments). B Representative western blots of 17aE2 (early and late) effects on pMEK3, MEK3, p-p38 and p38 protein levels separated by sex (males = M, females = F). C Bar graphs represent the mean ± SEM of pMEK3 ratios and MEK3 protein levels in liver samples from 16 young and 16 old mice plus, at least, 8 mice for each of the ACA and Rapa treatments groups. The 17aE2 was from 8 young males and 8 young females, 8 old males and 8 old female mice, while treatments represent a minimum of 4 mice for each treatment and sex group. All values have been normalized to young control females as described in the Methods section. The (*) indicates statistical significance (p < 0.05) in a t-test between the indicated pair of groups. D Bar graphs represent the mean ± SEM for p-p38 ratios and p38 protein levels as described above