Table 3.
Multiple regression analysis of factors associated with 1- and 2-year longitudinal changes in choroidal thickness in the central fovea
| Factor | Subfoveal choroidal thickness change (µm)a | |||
|---|---|---|---|---|
| One-year ∆thickness (95% CI) | P | Two-year ∆thickness (95% CI) | P | |
| Age (years) | − 2.36 (− 5.74 to 1.01) | 0.168 | − 4.41 (− 8.81 to 0.01) | 0.049 |
| Sex | − 16.39 (− 24.13 to − 8.66) | < 0.001 | − 17.25 (− 27.19 to − 7.32) | 0.001 |
| Lens | − 6.62 (− 14.44 to 1.18) | 0.096 | − 6.11 (− 16.02 to 3.79) | 0.227 |
| Baseline AL (mm) | − 8.87 (− 14.52 to − 3.21) | 0.002 | − 5.11 (− 12.30 to 2.07) | 0.163 |
| Baseline SER (D) | − 1.78 (− 7.66 to 4.09) | 0.355 | 2.96 (− 4.48 to 10.40) | 0.435 |
| Baseline whole retinal thickness (µm) | − 0.25 (− 0.46 to 0.03) | 0.024 | − 0.19 (− 0.47 to 0.07) | 0.158 |
| Baseline subfoveal choroidal thickness (µm) | − 0.06 (− 0.12 to 0.01) | 0.040 | − 0.08 (− 0.16 to − 0.001) | 0.046 |
| One-year AL change (mm) | − 49.66 (− 79.68 to − 19.64) | 0.001 | ||
| Two-year AL change (mm) | − 43.58 (− 71.41 to − 15.74) | 0.002 | ||
| One-year SER change (D) | 4.86 (− 5.22 to 14.95) | 0.345 | ||
| Two-year SER change (D) | 9.08 (− 1.07 to 19.23) | 0.080 | ||
CI= confidence interval; AL= axial length; SER= spherical equivalent of refraction
a∆Thickness changes are based on estimates determined by regression analysis; lens includes three groups of lenses worn by the participants: personalized progressive addition lenses (PPALs), fixed progressive addition lenses (FPALs), and single vision lenses (SVLs)