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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Bioorg Med Chem Lett. 2021 Apr 9;41:128025. doi: 10.1016/j.bmcl.2021.128025

Table 1:

Chemical structures and liver microsome stabilities of YM-08 analogs

graphic file with name nihms-1774016-t0001.jpg
Compound R1 R2 Percentage at T30min
YM-08 H 2-pyridinyl -
1 3-F 2-pyridinyl 12
2 4-F 2-pyridinyl 19
3 5-F 2-pyridinyl 5
4 6-F 2-pyridinyl 12
5 3-Cl 2-pyridinyl 38
6 4-Cl 2-pyridinyl 37
7 5-Cl 2-pyridinyl 13
8 6-Cl 2-pyridinyl 17
9 H 4-pyridinyl 6
10 3-F 4-pyridinyl 33
11 4-F 4-pyridinyl 23
12 5-F 4-pyridinyl 13
13 6-F 4-pyridinyl 30
14 3-Cl 4-pyridinyl n/t
15 (JG-23) 4-Cl 4-pyridinyl 52
16 5-Cl 4-pyridinyl 39
17 6-Cl 4-pyridinyl n/t