Table 1.
Risk Stratification Schema for First-Generation COG Renal Tumor Studies
| Stage | Histology | Age | Tumor Weight | LOH 1p/16q |
Lung Nodule Response | Extrapulmonary Metastases | Final Study |
|---|---|---|---|---|---|---|---|
| I | FH | <2 y ≥2 y |
≥550 g Any |
No No |
N/A N/A |
N/A | None |
| II | FH | Any | Any | No | N/A | N/A | None |
| I | FH | <2 y | <550 g | Any | N/A | N/A | AREN0532 |
| I/II | FH | Any | Any | Yes | N/A | N/A | AREN0532 |
| III | FH | Any | Any | No | N/A | N/A | AREN0532 |
| IV | FH | Any | Any | No | CR | No | AREN0533 |
| III/IV | FH | Any | Any | Yes | N/A | Any | AREN0533 |
| IV | FH | Any | Any | Any | IR | Any | AREN0533 |
| IV | FH | Any | Any | Any | Any | Yes | AREN0533 |
| I | DA FA |
Any | Any | Any | N/A | N/A | AREN0321 |
| II–III | FA | Any | Any | Any | N/A | N/A | AREN0321 |
| II | DA | Any | Any | Any | Any | N/A | AREN0321 |
| III | DA | Any | Any | Any | Any | N/A | AREN0321 |
| IV | DA FA |
Any | Any | Any | Any | Any | AREN0321 |
| V | Any | Any | Any | Any | Any | Any | AREN0534 |
Abbreviations: CR, complete response; DA, diffuse anaplasia; FA, focal anaplasia; FH, favorable histology; IR, incomplete response; LOH, loss of heterozygosity at both 1p and 16q; N/A, not available.