Table 4.
Prefrontal activity patterns induced by light stimulation of hippocampal terminals at neonatal and prejuvenile age
| Neonatal |
Prejuvenile |
|||||||
|---|---|---|---|---|---|---|---|---|
| CON L5/6 | GE L5/6 | F values | CON L5/6 | GE L5/6 | F values | |||
| Layer 5/6 stimulation |
Power (Stim-pre)/pre |
4–12 Hz | 0.807 ± 0.121 | 0.218 ± 0.096 |
F(1,23) = 3.365 p = 0.039 |
0.071 ± 0.036 | −0.02 ± 0.034 |
F(1,26) = 1.716 p = 0.190 |
| 12–30 Hz | 0.701 ± 0.141 | 0.216 ± 0.0562 |
F(1,23) = 1.779 p = 0.182 |
0.056 ± 0.027 | 0.042 ± 0.019 |
F(1,26) = 0.114 p = 0.735 |
||
| 30–45 Hz | 0.383 ± 0.062 | 0.151 ± 0.061 |
F(1,23) = 2.913 p = 0.0846 |
0.063 ± 0.043 | 0.079 ± 0.023 |
F(1,26) = 0.179 p = 0.673 |
||
| evoked LFP | Amplitude (µV) | 144.9 ± 26.97 | 67.0 ± 13.80 |
F(1,23) = 3.396 p = 0.024 |
70.8 ± 7.88 | 63.1 ± 3.43 |
F(1,26) = 0.007 p = 0.936 |
|
| Delay (ms) | 19.3 ± 0.40 | 19.3 ± 0.89 |
F(1,23) = 0.365 p = 0.552 |
17.5 ± 0.41 | 17.1 ± 0.57 |
F(1,26) = 0.392 p = 0.537 |
||
| Layer 2/3 stimulation |
Power (Stim-pre)/pre |
4–12 Hz | 0.289 ± 0.109 | 0.106 ± 0.135 |
F(1,21) = 2.314 p = 0.128 |
0.052 ± 0.029 | 0.0003 ± 0.031 |
F(1,26) = 1.517 p = 0.218 |
| 12–30 Hz | 0.285 ± 0.103 | 0.272 ± 0.142 |
F(1,21) = 0.314 p = 0.575 |
0.028 ± 0.028 | 0.036 ± 0.021 |
F(1,26) = 0.070 p = 0.792 |
||
| 30–45 Hz | 0.231 ± 0.074 | 0.098 ± 0.066 |
F(1,21) = 2.827 p = 0.093 |
0.044 ± 0.031 | 0.036 ± 0.030 |
F(1,26) = 0.008 p = 0.930 |
||
| evoked LFP | Amplitude (µV) | 132.3 ± 27.6 | 63.0 ± 17.94 |
F(1,21) = 3.939 p = 0.047 |
58.9 ± 8.20 | 39.7 ± 4.83 |
F(1,26) = 3.282 p = 0.07 |
|
| Delay (ms) | 19.8 ± 0.48 | 20.2 ± 0.68 |
F(1,21) = 0.013 p = 0.910 |
17.6 ± 0.32 | 17.2 ± 0.52 |
F(1,26) = 0.910 p = 0.350 |
||
Data are shown as mean ± SEM. Significance was assessed using one-way ANOVA test followed by Bonferroni-corrected post hoc test. The listed p values correspond to comparisons CON L5/6 versus GE L5/6 and CON L2/3 versus GE L2/3.