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. 2022 Feb;32(2):337–356. doi: 10.1101/gr.275387.121

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© 2022 Ziane et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see https://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — The asymmetric distribution of RNAPII on daughter chromatids is independent of the asymmetric distribution of new histones. Box plot distributions of lagging/leading ratios for replicated H3K56ac (dark blue) and replicated RNAPII (pink and green for early and early-mid S phase, respectively) in early (columns 1 and 2, respectively) and mid and early-mid (columns 3 and 4, respectively) S phase for early (rows A and C) and mid-early genes (rows B and D). (Header) Distribution of genome read densities, columns: (1) early S phase (MNase-NChAP, 60% unreplicated); (2) early S phase from Figure 2 (54% unreplicated); (3) bulk H3K56ac ChIP, mid S phase (6% unreplicated); (4) early-mid S phase (NChAP) from Figure 2B (10% unreplicated). (Rows A and B) Early and mid-early genes have been sorted by increasing lagging/leading RNAPII ratios from early S phase (Fig. 2B), respectively, and then divided into seven bins as in Figure 2B (y-axis), and box plot distributions of H3K56ac lagging/leading ratios (x-axis) from early (left) and mid (right) S phase have been determined (dark blue boxes) and compared with RNAPII lagging/leading ratios from early and early-mid S phase (pink and green boxes, respectively). The bar graphs on the left show the “same” gene enrichment calculated as in Figure 2B for gene bins indicated in the y-axis of each row on the right. (Rows C and D) As rows A and B but sorted by increasing lagging/leading RNAPII occupancy from early-mid S phase (Fig. 2B).